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MCB 539 Molecular and Biological Basis of Cancer: Lecture Schedule

MCB 539 MCB program Core Course Module Spring Quarter: March 27 - May 31, 2018

Time & Location

March 27 - May 31, 2018
Tuesday and Thursday

3:20-4:40 p.m.
FHCRC Weintraub bldg
Room B1-072/074

Course Textbook

Recommended Readings

The Emperor of all Maladies by Siddhartha Mukherjee

The Molecular Basis of Cancer by John Mendelsohn MD et al.


Conj 539 Course Description

Understanding and controlling cancer is one of the major challenges of 21st century biology. Contemporary research on cancer encompasses multiple disciplines including molecular and cellular biology, virology, structural biology, evolutionary genetics, genomics and epidemiology. This course consists of a series of lectures and discussion meetings to introduce students to the major themes in research on the etiology of neoplastic change. The lectures will cover principal molecular mechanisms responsible for tumor initiation, progression, and metastasis with a specific emphasis on oncogenic drivers and tumor suppressors and loss of normal tissue homeostasis. Background concepts and state of the art research with emphasis on current major questions in cancer biology will be presented by faculty who are experts in their fields. The discussion meetings will concentrate on selected major papers in cancer biology and be presented and discussed by the students with help and guidance of the instructors.

Grading:  Student overall participation, activity during discussions, quality and depth of the research paper presentation, and the written research proposal on one of the topics in cancer biology will be used for course credit and grading.  

Prerequisites: Introductory biochemistry and cell biology.

Enrollment in the course is limited to 20 students.

Lecture 1 - March 27, 2018

Introduction: Genetic basis of cancer

David MacPherson

Readings (copies available in eReserves)

Hallmarks of Cancer: The Next Generation
Hanahan, D. and Weinberg, R.
Cell 2011;144(5): 646-674

The Biology of Cancer. Weinberg (on reserve in Arnold Library)

Lecture 2 - March 29, 2018

MYC: An Oncogene Paradigm

Robert Eisenman

Readings in eReserve and book on reserve in Arnold Library copyroom

Lecture 3 - April 3, 2018

Cancer Epidemiology

Chris Li

Readings in eReserves

Lecture 4 - April 5, 2018

The Deranged Cancer Genome

Alice Berger

Readings in eReserves

Lecture 5 - April 10, 2018

HPV and Squamous Cell Cancer

Denise Galloway

Readings in eReserves

Lecture 6 - April 12, 2018

Protein Synthesis Control and Cancer

Andrew Hsieh

Readings in eReserves

Lecture 7 - April 17, 2018

Stem cell renewal and differentiation in tumorigenesis

Slobodan Beronja

Readings in eReserves

Lecture 8 - April 19, 2018

Targeting Metabolic Vulnerabilities in Cancer

David Hockenbery

Readings in eReserves

Lecture 9 - April 24, 2018

Literature Review 1

Slobodan Beronja

Relevant paper in eReserves

 

Lecture 10 - April 26, 2018

Cancer Genomics: Tools and Resources

Lisa McFerrin

Lecture 11 - May 1, 2018

Literature Review 2

Andrew Hsieh

Relevant reading in eReserves

 

Lecture 12 - May 3, 2018

Metastasis

Cyrus Ghajar

Readings in eReserves

Lecture 13 - May 8, 2018

Literature Review 3

David Hockenbery

Relevant reading in eReserves

 

 

Lecture 14 - May 10, 2018

Helicobacter pylori and Gastric cancer

Nina Salama

Readings available in eReserves

Lecture 15 - May 15, 2018

Cell Adhesion and Cancer

Valeri Vasioukhin

Readings in eReserves

Lecture 16 - May 17, 2018

Functional Genomics in Cancer Research

Patrick Paddison

Readings in eReserves

Lecture 17 - May 22, 2018

Cancer Immunotherapy

Stan Riddell

Lecture 18 - May 24, 2018

Literature Review 4

Nina Salama

Relevant Reading in eReserves

Lecture 19 - May 29, 2018

Prostate Cancer

Pete Nelson

Readings in eReserves

Lecture 20 - May 31, 2018

Literature Review 5

Cyrus Ghajar

Relevant Reading in eReserves

Course Instructors

Course organizers

David MacPherson
dmacpher@fredhutch.org

Bob Eisenman
eisenman@fredhutch.org

Lecturers

Alice Berger
ahberger@fredhutch.org

Slobodan Beronja
beronja@fredhutch.org

Bob Eisenman
eisenman@fredhutch.org

Denise Galloway
dgallowa@fredhutch.org

Cyrus Ghajar
cghajar@fredhutch.org

David Hockenbery
dhockenb@fredhutch.org

Andrew Hsieh
ahsieh@fredhutch.org

Chris Li
clll@fredhutch.org

Lisa McFerrin
lmcferri@fredhutch.org

Pete Nelson
pnelson@fredhutch.org

Patrick Paddison
paddison@fredhutch.org

Stanley Riddell
sriddell@fredhutch.org

Nina Salama
nsalama@fredhutch.org

Valera Vasioukhin
vvasiouk@fredhutch.org