1. A virtual library containing comprehensive list of links to fly information and resources.
2. A key internet resource for fly researchers.
3. A fun online exhibit of mutant flies.
4. Great images, movies and interactive features to explain fly development.
5. Encyclopedia of fly genes and development.
6. Where do the fly folks get the weird names for their genes? Not comprehensive but a fun website explaining the origins of fly nomenclature.
Fly (Drosophila melanogaster)
are available for viewing in the left column. View them before class to understand points about the following:
1. A excellent short review about the advantages of the fly model and some cancer lessons it has taught us.
2. Another great review on the importance of multicellular models like the fly in studying malignant changes in tissue size, migration and tumor microenvironment. Also, covers how discoveries in flies can guide human therapeutics.
3. An important article demonstrating how studies on a pathway controlling organ size in the fly lead to the identification of a homologous pathway in mammal, which when dysregulated caused tumorigenesis.
The following books are on course reserve in copy room of the the Arnold Library in the Weintraub building for two weeks.If you are interested in a more in depth view of Drosophila genetics and techniques take a look at books 2-4.
3. "Lords of the fly : Drosophila genetics and the experimental life"by Robert Kohler.
4. "The making of a fly : the genetics of animal design" by Peter Lawrence.
FHCRC scientists working with the fly model system:
1. Bruce Edgar: Cell cycle and cell growth in fly wing, eye, and intestinal stem cells
2. Robert Eisenman: Regulation of cell proliferation, growth and differentiation by transcription factors (Myc-Mad-Max)
3. Steven Henikoff: Epigenetic inheritance and chromatin structure
4. Harmit Malik: Evolutionary studies of genetic conflict
5. Susan Parkhurst: Fly development, wound healing, cytoskeletal dynamics, transcription repression
6. Suzanne Rutherford: Evolution, genetic variation