Autumn Quarter 2016
1.5 credits, weeks 1-5 (Sept 29 - Nov 1)
Tuesdays and Thursdays
Times: 3:20-4:40
Place: FHCRC B1-072
This course is a graduate level introduction to the chromosome. Topics this year will focus on the functions and evolution of chromosomal elements as well as the mechanisms that ensure the maintenance and propagation of chromosomes. The class will use a combination of lecture, literature review, and in-class discussion to explore genetic, biochemical, and cytological methods for defining our current knowledge about chromosomes. The course requires students to have taken undergraduate cell biology, biochemistry and genetics. Active participation in discussion is required.
Course registration is limited to 30 students. PLEASE EMAIL MARCI BURDEN (mburden@fredhutch.org) FOR ADD CODE. SUE BIGGINS IS NOT INVOLVED IN ASSIGNING THEM.
Lecture dates, topics and lecturer are listed below. Copies of all the readings are available in the eReserves (select the tab above).
Chromosome Introduction
Sue Biggins
Replication
Sue Biggins
Centromeres
Sue Biggins
Cohesion and Condensation
Sue Biggins
Epigenetics
Steve Henikoff
Telomeres
Sue Biggins
Evolution of mobile elements and chromosome structure
Harmit Malik
Genome Integrity
Sue Biggins
Chromosome Instability
Emily Hatch
Meiosis
Sue Biggins
Course Organizer:
Sue Biggins, Ph.D.
sbiggins@fredhutch.org
206-667-1351
Guest Lecturers:
Emily Hatch
ehatch@fredhutch.org
Steve Henikoff
steveh@fredhutch.org
Harmit Malik
hsmalik@fredhutch.org
Grades will be based on problem sets and class participation with the following distribution.
Problem Set 1: 25%
Problem Set 2: 50%
Participation: 25%