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Conj 552 Metabolic Flexibility   Tags: conj552, gottschling  

This course will focus on small molecules and the ways that the chemistry of these molecules facilitates life under changing conditions.
Last Updated: Aug 13, 2015 URL: Print Guide RSS UpdatesEmail Alerts

Course Info Print Page

Time & Location

September 26 - October 29, 2013
Tuesday and Thursday

3:20-4:40 p.m.
FHCRC Campus, Weintraub Bldg.
Room B1-072/074



Grading is based on class participation and regular presentation of assigned papers. In addtion, one or two problem sets may be assigned to reinforce concepts. 


Online Reference Books

Cover Art
Molecular Biology of the Cell - Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter
ISBN: 0815332181
Publication Date: 2002
4th edition is available online from NCBI/NLM. Search for topics, browsing is not activated

Cover Art
Biochemistry - Jeremy M Berg,1 John L Tymoczko,2 and Lubert Stryer
ISBN: 0716730510
Publication Date: 2002
5th edition is available online from NCBI/NLM. You can search for topics, but cannot browse.



See the E-Reserves page (yellow tab above) for the class reading assignments.

  • Thursday, Sep 26, 2013: (Gottschling)
    General concepts in metabolism control
  • Tuesday, Oct 1, 2013: (Gottschling)
    Glycolysis, TCA cycle and oxidative phosphorylation
  • Thursday, Oct 3, 2013: (Perez-Olsen)
    The biosynthesis and role of lipids and fatty acids in biology
  • Tuesday, Oct 8, 2013: (Valente)
    How cells sense and deal with rich and lean environments
  • Thursday, Oct 10, 2013: (Entwisle)
    Links between oxygen, respiration and nutrients
  • Tuesday, Oct 15, 2013: (Samanas)
    ROS and the immune system
  • Thursday, Oct 17, 2013: (Valente)
    Oncogene-induced senescence
  • Tuesday, Oct 22, 2013: (Entwisle)
    Metabolism in our guts...
  • Thursday, Oct 24, 2013: (Samanas)
    Mitochondrial "flashing"
  • Tuesday, Oct 29, 2013: The Final Event
    A difference of opinion in how antibiotics work.

CONJ 552 Faculty

Course Instructors:

Dan Gottschling
Fred Hutch; UW Genome Sciences

Guest Lecturer:

Carissa Perez-Olsen
Fred Hutch


Web-linked Resources

Nicholson Metabolic Pathways Wall Chart
This is a large wall chart of "central" metabolism with an emphasis on glycolysis, the TCA cycle and Oxidative phosphorylation. It provides a "big picture" perspective.

IUBMB Nicholson minimaps
These are a series of "mini-maps" that separate various portions of overall metabolism into simpler modules for focused discussion of regulation, energy production, etc.

KEGG Pathway Database
Wiring diagrams of molecular interactions, reactions, and relationships. Can be constrained to metabolic pathways in specific organisms.

ExPASy Metabolic Pathways Chart 

The original metabolic wall chart, now converted into a digital format with informative links.



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