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Conj 537 - Mechanisms of Transcriptional Regulation  

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription.
Last Updated: Aug 13, 2015 URL: Print Guide RSS UpdatesEmail Alerts

Class Schedule Print Page

Time & Location

Autumn Quarter 2014

1.5 credits, weeks 6-10 (Oct 30 - Dec 4)

Tuesdays and Thursdays

Times: 3:20-4:40

Place: FHCRC B1-072-074


Course Description

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Transcriptional regulation, development and diseases in mammals (Steve Tapscott).


Lecture Schedule

Lecture dates, topics and lecturer are listed below. Copies of all the readings are available in the eReserves (select the tab above).

Lectures will be ready for downloading the day after the lecture and can also be found in eReserves.

A copy of the entire lecture schedule is available for download below.


Lecture 1 - Oct 30, 2014

Transcriptional Regulatory Mechanisms in Prokaryotes
Steve Hahn


Lecture 2 - Nov 4, 2014

Mechanisms of RNA Polymerase II initiation and elongation
Steve Hahn


Lecture 3 - Nov 6, 2014

Eukaryotic promoters, enhancers and other regulatory elements
Steve Hahn


Lecture 4 - Nov 13, 2014

Enhancers, coactivators and transcription activation mechanisms
Steve Hahn

Homework#1 to be handed out.


Lecture 5 - Nov 18, 2014

Chromatin and Transcription: General Overview
Toshi Tsukiyama


Lecture 6 - Nov 20, 2014

Histone Modifying Enzymes
Toshi Tsukiyama


Lecture 7 - Nov 25, 2014

ATP-dependent Chromatin Remodeling Factors
Toshi Tsukiyama

Homework #1 due

Homework #2 to be handed out



lecture 8 - Dec 2, 2014

Promoter-specific and Regional Regulation of Transcription
Steve Tapscott

Homework #1 to be returned


Lecture 9 - Dec 4, 2014

Dynamic and Compex Patterns of Gene Expression
Steve Tapscott

Homework #2 due

Homework #3 handed out (due Dec 11 and can be dropped off at Mailstop C3-168 or emailed to

Homework #2 and #3 can be picked up after 12/11 (#2) and 12/17 (#3) at A1-175 (#2) and C3-168 (#3).

Subject Guide

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Contact Info
Mailstop: B1-010
phone: x.4314
fax: x.4737
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Course Organizer

Course Organizer:

Toshio Tsukiyama, Ph.D.

Additional Lecturers:

Steve Hahn

Steve Tapscott


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