A collaborative platform and preprint server for creating and sharing science methods, computational workflows, clinical trials, operational procedures, safety checklists, instructions and manuals. All public content on protocols.io is open access and free to read and publish. Thanks to a campus-wide license, all Fred Hutchinson Cancer Center employees have free Premium individual and team plans. See our protocols.io institutional page for examples of published Fred Hutch protocols. New users can create an account at https://www.protocols.io/organizations/fhcc/banner.