Autumn Quarter 2024
1.5 credits, weeks 6-10 (Nov 3 - Dec 6)
Tuesdays and Thursdays
Times: 1:40-3:00
Place: Fred Hutch B1-076 (Weintraub building)
A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Chromatin dysregulation in cancer (Sita Kugel); Chromatin control during infection (Daphne Avgousti.
Lecture dates, topics and lecturer are listed below. Copies of all the readings are available in the eReserves (select the tab above).
Lecture slides will be ready for downloading by the day of the lecture and can also be found in eReserves.
A copy of the entire lecture schedule is available for download above.
RNA polymerases and transcription mechanisms
Steve Hahn
Regulation of transcription elongation
Steve Hahn
Topics in transcriptional regulation
Steve Hahn
Homework #1 to be handed out (due 11/19/2024)
Chromatin and transcription: General overview
Toshi Tsukiyama
Histone modifying enzymes
Toshi Tsukiyama
Homework 1 Due
ATP-dependent chromatin remodeling factors
Toshi Tsukiyama
Homework #2 to be handed out (due 12/3/2024)
Structural basis of the transcriptional regulation in chromatin
Yasu Arimura
A Brief History of Transcriptomics Techniques
Sanjay Srivastan
Homework #2 due
Translation and its control
Chris Lapointe
Course Organizer:
Toshio Tsukiyama, Ph.D.
ttsukiya@fredhutch.org
Additional Lecturers:
Steve Hahn
shahn@fredhutch.org
Sita Kugel
skugel@fredhutch.org
Daphne Avgousti
avgousti@fredhutch.org