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Conj 537 Mechanisms of Transcriptional Regulation: Class Schedule

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription.

Time & Location

Autumn Quarter 2022

1.5 credits, weeks 6-10 (Nov 3 - Dec 6)

Tuesdays and Thursdays

Times: 1:40-3:00

Place: Fred Hutch B1-076 (Weintraub building)

Course Description

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Chromatin dysregulation in cancer (Sita Kugel); Chromatin control during infection (Daphne Avgousti.

Lecture Schedule

Lecture dates, topics and lecturer are listed below. Copies of all the readings are available in the eReserves (select the tab above).

Lecture slides will be ready for downloading by the day of the lecture and can also be found in eReserves.

A copy of the entire lecture schedule is available for download above.

Lecture 1 - Nov 3, 2022

RNA polymerases and regulation by phosphorylation
Steve Hahn


Lecture 2 - Nov 8 2022

Transcription elongation and regulation by Polymerase pausing
Steve Hahn

Lecture 3 - Nov 10, 2022

Transcription initiation, promoters, and TBP-DNA loading mechanisms
Steve Hahn

Lecture 4 - Nov 15, 2022

Enhancers, coactivators, transcription factors, and gene activation/repression
Steve Hahn

Homework#1 to be handed out (due 11/22/22)

Lecture 5 - Nov 17, 2022

Chromatin and Transcription: General Overview
Toshi Tsukiyama



Lecture 6 - Nov 22, 2022

Histone Modifying Enzymes
Toshi Tsukiyama

Homework #1 due

lecture 7 - Nov 29, 2022

ATP-dependent chromatin remodeling factors
Toshi Tsukiyama

Homework #2 to be handed out (due 12/6/22)



Lecture 8 - Dec 01, 2022

Chromatin control during infection
Daphne Avgousti​​​​​​​


Lecture 9 - Dec 06, 2022

Chromatin dysregulation in Cancer
Sita Kugel


Topic: CONJ 537 Mechanisms of Transcriptional Regulation

Time: Dec 6, 2022 01:40 PM Pacific Time (US and Canada)

Join Zoom Meeting

Meeting ID: 871 1401 5434

Passcode: 983672

One tap mobile

+12532050468,,87114015434#,,,,*983672# US

+12532158782,,87114015434#,,,,*983672# US (Tacoma)

Homework #2 due

Course Organizer

Course Organizer:

Toshio Tsukiyama, Ph.D.

Additional Lecturers:

Steve Hahn

Sita Kugel 

Daphne Avgousti