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Conj 537 Mechanisms of Transcriptional Regulation: Class Schedule

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription.

Time & Location

Autumn Quarter 2018

1.5 credits, weeks 6-10 (Nov 2 - Dec 5)

Tuesdays and Thursdays

Times: 3:20-4:40

Place: FHCRC B1-072

Course Description

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Transcriptional regulation, development and diseases in mammals (Steve Tapscott).

Lecture Schedule

Lecture dates, topics and lecturer are listed below. Copies of all the readings are available in the eReserves (select the tab above).

Lecture slides will be ready for downloading by the day of the lecture and can also be found in eReserves.

A copy of the entire lecture schedule is available for download above.

Lecture 1 - Nov 1, 2018

Transcriptional Regulatory Mechanisms in Prokaryotes
Steve Hahn

Lecture 2 - Nov 6 2018

Mechanisms of RNA Polymerase II initiation and elongation
Steve Hahn

Lecture 3 - Nov 8, 2018

Eukaryotic promoters, enhancers and other regulatory elements
Steve Hahn

Lecture 4 - Nov 13, 2018

Enhancers, coactivators and transcription activation mechanisms
Steve Hahn

Homework#1 to be handed out.(due 11/20)

Lecture 5 - Nov 15, 2018

Chromatin and Transcription: General Overview
Toshi Tsukiyama

Lecture 6 - Nov 20, 2018

Histone Modifying Enzymes
Toshi Tsukiyama

Homework #1 due

lecture 7 - Nov 27, 2018

ATP-dependent chromatin remodeling factors
Toshi Tsukiyama

Homework #2 to be handed out (due 12/4)

Homework #1 to be returned


Lecture 8 - Nov 290, 2018

Promoter-specific and regional regulation of transcription
Stephen Tapscott



Lecture 9 - Dec 4, 2018

Dynamic and Compex Patterns of Gene Expression
Stephen Tapscott

Homework #3 handed out (due Dec 11). Homework should be e-mailed to

Homework #2 and #3 can be picked up after 12/11 (#2) and 12/18 (#3) at A1-175 (#2) and C3-168 (#3).

Course Organizer

Course Organizer:

Toshio Tsukiyama, Ph.D.

Additional Lecturers:

Steve Hahn

Steve Tapscott