Autumn Quarter 2020
1.5 credits, weeks 6-10 (Nov 5 - Dec 8)
Tuesdays and Thursdays
A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Chromatin dysregulation in cancer (Sita Kugel); Chromatin control during infection (Daphne Avgousti.
Lecture dates, topics and lecturer are listed below. Copies of all the readings are available in the eReserves (select the tab above).
Lecture slides will be ready for downloading by the day of the lecture and can also be found in eReserves.
A copy of the entire lecture schedule is available for download above.
RNA polymerases and regulation by phosphorylation
•Homework #1 to be handed out (due 12/01)
Transcription elongation and regulation by Polymerase pausing
Transcription initiation, promoters, and TBP-DNA loading mechanisms
Enhancers, coactivators, transcription factors, and gene activation/repression
Homework#1 to be handed out.(due 11/20)
Chromatin and Transcription: General Overview
Histone Modifying Enzymes
Homework #1 due
ATP-dependent chromatin remodeling factors
Homework #2 to be handed out (due 12/4)
Homework #1 to be returned
Chromatin dysregulation in Cancer
Chromatin control during infection
•Homework #2 due