Autumn Quarter 2018
1.5 credits, weeks 6-10 (Nov 2 - Dec 5)
Tuesdays and Thursdays
Place: FHCRC B1-072
A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Transcriptional regulation, development and diseases in mammals (Steve Tapscott).
Lecture dates, topics and lecturer are listed below. Copies of all the readings are available in the eReserves (select the tab above).
Lecture slides will be ready for downloading by the day of the lecture and can also be found in eReserves.
A copy of the entire lecture schedule is available for download above.
Transcriptional Regulatory Mechanisms in Prokaryotes
Mechanisms of RNA Polymerase II initiation and elongation
Eukaryotic promoters, enhancers and other regulatory elements
Enhancers, coactivators and transcription activation mechanisms
Homework#1 to be handed out.(due 11/20)
Chromatin and Transcription: General Overview
Histone Modifying Enzymes
Homework #1 due
ATP-dependent chromatin remodeling factors
Homework #2 to be handed out (due 12/4)
Homework #1 to be returned
Promoter-specific and regional regulation of transcription
Dynamic and Compex Patterns of Gene Expression
Homework #3 handed out (due Dec 11). Homework should be e-mailed to email@example.com.
Homework #2 and #3 can be picked up after 12/11 (#2) and 12/18 (#3) at A1-175 (#2) and C3-168 (#3).