MCB 539 Biological Basis of Neoplasia: Lecture Schedule

Tuesdays and Thursdays

3:30 - 4:50 PM

Room B1-072/074 (next to Pelton Auditorium), Weintraub Building, Fred Hutch Campus

Understanding and controlling cancer is one of the major challenges of 21^st century biology. Contemporary research on cancer encompasses multiple disciplines including molecular and cellular biology, virology, structural biology, evolutionary genetics, genomics and epidemiology. This course consists of a series of lectures and discussion meetings to introduce students to the major themes in research on the etiology of neoplastic change. The lectures will cover principal molecular mechanisms responsible for tumor initiation, progression, and metastasis with a specific emphasis on oncogenic drivers and tumor suppressors and loss of normal tissue homeostasis. Background concepts and state of the art research with emphasis on current major questions in cancer biology will be presented by faculty who are experts in their fields. The discussion meetings will concentrate on selected major papers in cancer biology and be presented and discussed by the students with help and guidance of the instructors.

Grading: Student overall participation, activity during discussions, quality and depth of the research paper presentation, and the written research proposal on one of the topics in cancer biology will be used for course credit and grading.

Prerequisites: Introductory biochemistry and cell biology.

Enrollment in the course is limited to 20 students.

Introduction: Genetic Basis of Cancer

David MacPherson, PhD

MYC: An Oncogene Paradigm

Bob Eisenman, PhD

Cancer Metabolism

Lucas Sullivan, PhD

Cancer Genomics

Alice Berger, PhD

Functional Genomics

Patrick Paddison, PhD

Hematopoietic Neoplasia

Stanley Lee, PhD

Faculty Discussant: Alice Berger

Alice Berger, PhD

Viruses and Cancer

Denise Galloway, PhD

Cancer Immunology and Immunotherapy

Philip Greenberg, MD

Origins and Properties of Neoplastic Cells

Slobodan Beronja, PhD

Helicobacter pylori and cancer

Nina Salama, PhD

Metastasis

Cyrus Ghajar, PhD

Faculty Discussant: Patrick Paddison, PhD

DNA Damage Response and Cancer

Richard Adeyemi, DVM, PhD

Tumor Cell Behavior and Dynamics

Kevin J. Cheung, MD

Literature Review 3

Faculty Discussant: Kevin Cheung, MD

Prostate Cancer

Michael Haffner, MD, PhD

Faculty Discussant: Cyrus Ghajar, PhD

Targeting degradation of oncogenic proteins

Behnam Nabet, PhD

Faculty Discussant: Slobodan Beronja, PhD