March 27 - May 31, 2018
Tuesday and Thursday
3:20-4:40 p.m.
FHCRC Weintraub bldg
Room B1-072/074
The Biology of Cancer
by 
Understanding and controlling cancer is one of the major challenges of 21st century biology. Contemporary research on cancer encompasses multiple disciplines including molecular and cellular biology, virology, structural biology, evolutionary genetics, genomics and epidemiology. This course consists of a series of lectures and discussion meetings to introduce students to the major themes in research on the etiology of neoplastic change. The lectures will cover principal molecular mechanisms responsible for tumor initiation, progression, and metastasis with a specific emphasis on oncogenic drivers and tumor suppressors and loss of normal tissue homeostasis. Background concepts and state of the art research with emphasis on current major questions in cancer biology will be presented by faculty who are experts in their fields. The discussion meetings will concentrate on selected major papers in cancer biology and be presented and discussed by the students with help and guidance of the instructors.
Grading: Student overall participation, activity during discussions, quality and depth of the research paper presentation, and the written research proposal on one of the topics in cancer biology will be used for course credit and grading.
Prerequisites: Introductory biochemistry and cell biology.
Enrollment in the course is limited to 20 students.
Introduction: Genetic basis of cancer
David MacPherson
Readings (copies available in eReserves)
Hallmarks of Cancer: The Next Generation
Hanahan, D. and Weinberg, R.
Cell 2011;144(5): 646-674
The Biology of Cancer. Weinberg (on reserve in Arnold Library)
MYC: An Oncogene Paradigm
Robert Eisenman
Readings in eReserve and book on reserve in Arnold Library copyroom
Cancer Epidemiology
Chris Li
Readings in eReserves
The Deranged Cancer Genome
Alice Berger
Readings in eReserves
HPV and Squamous Cell Cancer
Denise Galloway
Readings in eReserves
Protein Synthesis Control and Cancer
Andrew Hsieh
Readings in eReserves
Stem cell renewal and differentiation in tumorigenesis
Slobodan Beronja
Readings in eReserves
Targeting Metabolic Vulnerabilities in Cancer
David Hockenbery
Readings in eReserves
Literature Review 1
Slobodan Beronja
Relevant paper in eReserves
Cancer Genomics: Tools and Resources
Lisa McFerrin
Literature Review 2
Andrew Hsieh
Relevant reading in eReserves
Metastasis
Cyrus Ghajar
Readings in eReserves
Literature Review 3
David Hockenbery
Relevant reading in eReserves
Helicobacter pylori and Gastric cancer
Nina Salama
Readings available in eReserves
Cell Adhesion and Cancer
Valeri Vasioukhin
Readings in eReserves
Functional Genomics in Cancer Research
Patrick Paddison
Readings in eReserves
Cancer Immunotherapy
Stan Riddell
Literature Review 4
Nina Salama
Relevant Reading in eReserves
Prostate Cancer
Pete Nelson
Readings in eReserves
Literature Review 5
Cyrus Ghajar
Relevant Reading in eReserves
Course organizers
David MacPherson
dmacpher@fredhutch.org
Bob Eisenman
eisenman@fredhutch.org
Lecturers
Alice Berger
ahberger@fredhutch.org
Slobodan Beronja
beronja@fredhutch.org
Bob Eisenman
eisenman@fredhutch.org
Denise Galloway
dgallowa@fredhutch.org
Cyrus Ghajar
cghajar@fredhutch.org
David Hockenbery
dhockenb@fredhutch.org
Andrew Hsieh
ahsieh@fredhutch.org
Chris Li
clll@fredhutch.org
Lisa McFerrin
lmcferri@fredhutch.org
Pete Nelson
pnelson@fredhutch.org
Patrick Paddison
paddison@fredhutch.org
Stanley Riddell
sriddell@fredhutch.org
Nina Salama
nsalama@fredhutch.org
Valera Vasioukhin
vvasiouk@fredhutch.org