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Conj 533 The Dynamic Chromosome: Class Schedule

Time & Location

Autumn Quarter 2016

1.5 credits, weeks 1-5 (Sept 29 - Nov 1)

Tuesdays and Thursdays

Times: 3:20-4:40

Place: FHCRC B1-072

Course Description

This course is a graduate level introduction to the chromosome. Topics this year will focus on the functions and evolution of chromosomal elements as well as the mechanisms that ensure the maintenance and propagation of chromosomes. The class will use a combination of lecture, literature review, and in-class discussion to explore genetic, biochemical, and cytological methods for defining our current knowledge about chromosomes. The course requires students to have taken undergraduate cell biology, biochemistry and genetics. Active participation in discussion is required.

Course registration is limited to 30 students.  PLEASE EMAIL MARCI BURDEN (mburden@fredhutch.org) FOR ADD CODE.  SUE BIGGINS IS NOT INVOLVED IN ASSIGNING THEM.

Lecture Schedule

Lecture dates, topics and lecturer are listed below. Copies of all the readings are available in the eReserves (select the tab above).

Lecture 1 - Sept 29, 2016

Chromosome Introduction
Sue Biggins

Lecture 2 - October 4, 2016

Replication
Sue Biggins

Lecture 3 - Oct 6, 2016

Centromeres
Sue Biggins

Lecture 4 - Oct 11, 2016

Cohesion and Condensation
Sue Biggins

Lecture 5 - Oct 13, 2016

Epigenetics
Steve Henikoff

Lecture 6 - Oct 18, 2016

Telomeres
Sue Biggins 

Lecture 7 - Oct 20, 2016

Evolution of mobile elements and chromosome structure
Harmit Malik

Lecture 8 - Oct 25, 2016

Genome Integrity
Sue Biggins

Lecture 9 - Oct 27, 2016

Chromosome Instability
Emily Hatch

Lecture 10 - Nov 1, 2016

Meiosis
Sue Biggins

Course Organizer

Course Organizer:

Sue Biggins, Ph.D.
sbiggins@fredhutch.org
206-667-1351

Guest Lecturers:

Emily Hatch  
ehatch@fredhutch.org

Steve Henikoff 
steveh@fredhutch.org

Harmit Malik
hsmalik@fredhutch.org

Grading

Grades will be based on problem sets and class participation with the following distribution.

Problem Set 1: 25%

Problem Set 2: 50%

Participation: 25%