Compare cell division in budding yeast to cell division in human cells in video above.
Breast cancer cell division - timelapse video over 3 days
Narrated animation describing the stages of the cell cycle.
Yeast (Saccharomyces cerevisiae)
Lecture videos are available for viewing in the left column. They illustrate key points about the following:
The Cell cycle
Human cell versus yeast cell division
The Yeast two-hybrid technique
Required/Encouraged Reading
1. An overview for the interested layperson
L. H. Hartwell's Yeast: A Model Organism for Studying Somatic Mutations and Cancer
2. A more in-depth recounting of yeast and the cell cycle
Yeast and Cancer: Leland Hartwell, Nobel Lecture
3. Review of yeast techniques in the 'omics era
Yeast-based functional genomics and proteomics technologies: the first 15 years and beyond
Additional Reading
Yeast as a model system for anti-cancer drug discovery
Lecture Slides
The following books are on course reserve in the the Arnold Library, Weintraub building for two weeks. If you are interested in a more in depth view of the topics covered take a look.
FHCRC scientists working with the yeast model system:
1. Sue Biggins: Chromosome seggregation
2. Linda Breeden: Control of cell division
3. Antonio Bedalov: Drug discovery
4. Dan Gottschling: Aging
5. Steven Hahn: Transcriptional regulation
6. Amanda Paulovich: DNA damage response
7. Julian Simon: Anti-cancer drugs
8. Gerry Smith: Meiotic recombination in the fission yeast
Schizosaccharomyces pombe
9. Toshi Tsukiyama: Chromatin regulation
1. There is a virtual library in the Saccharomyces
genome database website. For general topics look in: http://www.yeastgenome.org/VL-yeast.html 2. An online book on yeast
molecular biology. A compedium on basic features and novel aspects by Horst
Feldmann at the University of Munich. http://biochemie.web.med.uni-muenchen.de/Yeast_Biol/ 3. "An Introduction to the
Genetics and Molecular Biology of the Yeast Saccharomyces cerevisiae" by Fred
Sherman http://dbb.urmc.rochester.edu/labs/sherman_f/yeast/index.html 4. The Yeast Resource Center
of The National Center for
Research Resources is located right here in Seattle! The center provides
expertise and access to 5 advanced technologies: mass spectrometry, yeast
two-hybrid arrays, deconvolution fluorescence microscopy, protein structure
prediction, and computational biology. http://depts.washington.edu/yeastrc/